(9/19/15 Update) Note: This spoiler is out of date. The Second Edition will now be Crazier Eights: Camelot. See the spoiler here.
The First Edition of Crazier eights had thirteen unique cards, and each of them appeared in all four colors. The Second Edition of Crazier Eights has fifty two unique cards. Every card in the set has a different effect, and the increase in variety comes with an even greater number of interesting card interactions. The rules are the same as the First Edition, but some additional rules clarifications will also be available. (Note that this spoiler is of a prototype of the game, so the appearance and cards could change.)